Publications

2023

Gang Wang, Jianlong Li, Linda Bojmar, Haiyan Chen, Zhong Li, Gabriel C. Tobias, Mengying 2 Hu1,  Edwin Homan, Serena Lucotti,  Fengbo Zhao,  Valentina  Posada,  Peter Oxley, Michele Cioffi, Han Sang Kim, Huajuan Wang, Pernille Lauritzen, Nancy Boudreau, Zhanjun Shi, Christin 4 E. Burd8, Jonathan H. Zippin, James C. Lo, Geoffrey S. Pitt, Jonathan Hernandez, Constantinos Zambirinis, Michael Hollingsworth, Paul M. Grandgenett, Maneesh Jain, Surinder K. Batra, Dominick DiMaio, Jean L. Grem, Kelsey A. Klute, Tanya M. Trippett, Mikala Egeblad, Doru Paul, Jacqueline Bromberg, David Kelsen, Vinagolu K. Rajasekhar, John H. Healey, Irina R. Matei, William R. Jarnagin, Robert E. Schwartz*, Haiying Zhang*, and David Lyden*. Tumor extracellular vesicles and particles dysregulate liver metabolism. Nature. In Press. *Co-corresponding author and co-senior author

Avital Licht-Murava, Samantha M. Meadows, Fernando Palaguachi, Soomin C. Song, Stephanie Jackvony, Yaron Bram, Constance Zhou, Robert E. Schwartz, Robert C. Froemke, Adam L. Orr, and Anna G. Orr. Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines. Science Advances. 9(16). 2023 Apr 19. PMID: 37075107.

X Tang, D Xue, T Zhang, BE Nilsson-Payant, L Carrau, X Duan, M Gordillo, AY Tan, Y Qiu, J Xiang, RE Schwartz*, BR tenOever*, T Evans*, S Chen*. A multi-organoid platform identifies CIART as a key factor for SARS-CoV-2 infection. Nature Cell Biology volume 25, pages 381–389 (2023). PMID: 36918693.

A Buckholz, L Clarke, P  Paik, A Jesudian, Robert E. Schwartz, Ana Krieger, R Rosenblatt, RS Brown Jr. Evaluating sleep in covert encephalopathy with wearable technology: results from the WATCHES study. Hepatol Commun. 2023 Feb 1;7(2). PMID: 36724117. *Co-corresponding author and co-senior author

2022

Y Bram, X Duan, BE. Nilsson-Payant, V Chandar, B tenOever*, Shuibing Chen*, and Robert E Schwartz*. Dual-Reporter System for Real-Time Monitoring of SARS-CoV-2 Main Protease Activity in Live Cells Enables Identification of an Allosteric Inhibition Path. ACS Bio & Med Chem Au. 2022 Oct 17; 2(6):627-641. *Corresponding author and co-senior author. PMID: 36570071.

Paôline Laurent, Chao Yang, André F Rendeiro, Benjamin E Nilsson-Payant, Lucia Carrau, Vasuretha Chandar, Yaron Bram, Benjamin R tenOever, Olivier Elemento, Lionel B Ivashkiv, Robert E Schwartz*, Franck J Barrat*. Sensing of SARS-CoV-2 by pDCs and their subsequent production of IFN-I contribute to macrophage-induced cytokine storm during COVID-19. Science Immunology. 7 (75), 2022. *Co-corresponding author and co-senior author. PMID: 36083891.

Tomer M Yaron, Brook E Heaton, Tyler M Levy, Jared L Johnson, Tristan X Jordan, Benjamin M Cohen, Alexander Kerelsky, Ting-Yu Lin, Katarina M Liberatore, Danielle K Bulaon, Samantha J Van Nest, Nikos Koundouros, Edward R Kastenhuber, Marisa N Mercadante, Kripa Shobana-Ganesh, Long He, Robert E Schwartz, Shuibing Chen, Harel Weinstein, Olivier Elemento, Elena Piskounova, Benjamin E Nilsson-Payant, Gina Lee, Joseph D Trimarco, Kaitlyn N Burke, Cait E Hamele, Ryan R Chaparian, Alfred T Harding, Aleksandra Tata, Xinyu Zhu, Purushothama Rao Tata, Clare M Smith, Anthony P Possemato, Sasha L Tkachev, Peter V Hornbeck, Sean A Beausoleil, Shankara K Anand, François Aguet, Gad Getz, Andrew D Davidson, Kate Heesom, Maia Kavanagh-Williamson, David A Matthews, Benjamin R tenOever, Lewis C Cantley, John Blenis, Nicholas S Heaton. Host protein kinases required for SARS-CoV-2 nucleocapsid phosphorylation and viral replication. Science Signaling. 15 (757). PMID: 36282911.

Yuling Han, Lei Tan, Ting Zhou, Liuliu Yang, Lucia Carrau, Lauretta A Lacko, Mohsan Saeed, Jiajun Zhu, Zeping Zhao, Benjamin E Nilsson-Payant, Filipe Tenorio Lira Neto, Clare Cahir, Alice Maria Giani, Jin Chou Chai, Yang Li, Xue Dong, Dorota Moroziewicz, The NYSCF Global Stem Cell Array, Daniel Paull, Tuo Zhang, Soyeon Koo, Christina Tan, Ron Danziger, Qian Ba, Lingling Feng, Zhengming Chen, Aaron Zhong, Gilbert J Wise, Jenny Z Xiang, Hui Wang, Robert E Schwartz, Scott A Noggle, Charles M Rice, Qibin Qi, Todd Evans, Shuibing Chen. A human iPSC-array-based GWAS identifies a virus susceptibility locus in the NDUFA4 gene and functional variants. Cell Stem Cell. 2022: 29:10 1475-1490. PMID: 36206731.

Yongzhen Liu, Debby Park, Thomas R Cafiero, Yaron Bram, Vasuretha Chandar, Anna Tseng, Hans P Gertje, Nicholas A Crossland, Lishan Su, Robert E Schwartz*, Alexander Ploss*. Molecular clones of genetically distinct hepatitis B virus genotypes reveal distinct host and drug treatment responses. JHep Reports. 4 (9)  2022. *Co-corresponding author and co-senior author. PMID: 36035359.

Jin JC, Ananthanarayanan A, Brown JA, Rager SL, Bram Y, Sanidad KZ, Amir M, Baergen RN, Stuhlmann H, Schwartz RE, Perlman JM, Zeng MY. SARS CoV-2 detected in neonatal stool remote from maternal COVID-19 during pregnancy. Pediatr Res. 2022 Aug 19. doi: 10.1038/s41390-022-02266-7. PMID: 35986143.

D Yang, H Cho, Z Tayyebi, A Shukla, R Luo, G Dixon, V Ursu, S Stransky,  Daniel M Tremmel, Sara D Sackett, Richard Koche, Samuel J Kaplan, Qing V Li, Jiwoon Park, Zengrong Zhu, Bess P Rosen, Julian Pulecio, Zhong-Dong Shi, Yaron Bram, Robert E. Schwartz, Jon S Odorico, Simone Sidoli, Christopher V Wright, Christina S Leslie, Danwei Huangfu CRISPR screening uncovers a central requirement for HHEX in pancreatic lineage commitment and plasticity restriction. Nature Cell Biology, 24, 1064–1076 (2022). PMID: 35787684.

K Oishi, S Horiuchi, J Frere, RE Schwartz and BR tenOever. A diminished immune response underlies age-related SARS-CoV-2 pathologies. Cell Reports 39 (13), 111002. PMID: 35714615.

JJ Frere, RA Serafini, KD Pryce, M Zazhytska, K Oishi, I Golynker, M Panis, Jeffrey Zimering, Shu Horiuchi, Daisy A Hoagland, Rasmus Møller, Anne Ruiz, Albana Kodra, Jonathan B Overdevest, Peter D Canoll, Alain C Borczuk, Vasuretha Chandar, Yaron Bram, Robert E. Schwartz, Stavros Lomvardas, Venetia Zachariou, Benjamin R tenOever. SARS-CoV-2 infection in hamsters and humans results in lasting and unique systemic perturbations post recovery. Science Translational Medicine. PMID: 35857629.

D Batlle, V Monteil, E Garreta, L Hassler, J Wysocki, V Chandar, Robert E Schwartz, Ali Mirazimi, Nuria Montserrat, Michael Bader, Josef M Penninger. Evidence in favor of the essentiality of human cell membrane-bound ACE2 and against soluble ACE2 for SARS-CoV-2 infectivity. Cell 185 (11), 1837-1839. PMID: 35623327.

Jesus Maria Gómez-Salinero, Franco Izzo, Balvir Kunar, Yang Lin, Fuqiang Geng, Sean Houghton, David Redmond, Jiwoon Park, Yaron Bram, Jose Jessurun, Tomer Itkin, Robert P. Adelson, David Barry, Yen-Michael Sheng Hsu, Giorgio Ga. Inghirami5, Jenny Zhaoying Xiang, Raphael Lis, Sina Y. Rabbany, Dan A. Landau, Robert E. Schwartz*, and Shahin Rafii* Specification of fetal liver endothelial progenitors to functional zonated adult sinusoids requires c-Maf induction. Cell Stem Cell. Cell Stem Cell 29 (4), 593-609. *Co-corresponding author PMID: 35364013.

Argueta LB, Lacko LA, Bram Y, Tada T, Carrau L, Zhang T, Uhl S, Lubor BC, Chandar V, Gil C, Zhang W, Dodson B, Bastiaans J, Prabhu M, Salvatore CM, Yang YJ, Baergen RN, tenOever BR, Landau NR, Chen S, Schwartz RE*, Stuhlmann H*. Inflammatory Responses in the Placenta upon SARS-CoV-2 Infection Late in Pregnancy. iScience, 1042239. *Co-corresponding author. PMID: 35434541.

Y Han, J Zhu, L Yang, BE Nilsson-Payant, R Hurtado, LA Lacko, X Sun, AR Gade, CA Higgins, WJ Sisso, X Dong, M Wang, Z Chen, DD Ho, GS Pitt, RE Schwartz*, BT tenOever*, T Evans*, and S Chen*. SARS-CoV-2 infection induces ferroptosis of sinoatrial node pacemaker cells. Circulation Research 130 (7), 963-977. *Co-corresponding author. PMID: 35255712.

ER Kastenhuber, JL Johnson, M Mercadante, JA Jaimes, F Muecksch, Y Weisblum, Y Bram, GR Whittaker, RE Schwartz, and LC Cantley. Coagulation factors directly cleave SARS-CoV-2 spike and enhance viral entry. Elife. 2022 Mar 23;11:e77444. doi: 10.7554/eLife.77444. PMID: 35294338.

Adrover JM, Carrau L, Daßler-Plenker J, Bram Y, Chandar V, Houghton S, Redmond D, Merrill JR, Shevik M, tenOever BR, Lyons SK, Schwartz RE*, Egeblad M*. Disulfiram inhibits neutrophil extracellular trap formation protecting rodents from acute lung injury and SARS-CoV-2 infection. JCI Insight. 2022 Feb 8:e157342. PMID: 35133984 *Co-corresponding author.

Jiwoon Park, Jonathan Foox, Tyler Hether, David Danko, Sarah Warren, Youngmi Kim, Jason Reeves, Danel J Butler, Christopher Mozsary, Joel Rosiene, Alon Shaiber, Ebrahim Afshinnekoo, Matthew MacKay, Yaron Bram, Vasuretha Chandar, Heather Geiger, Arryn Craney, Priya Velu, Ari M Melnick, Iman Hajirasouliha, Afshin Beheshti, Deanne Taylor, Amanda Saravia-Butler, Urminder Singh, Eve Syrkin Wurtele, Jonathan Schisler, Samantha Fenessey, Andre Corvelo, Michael C Zody, Soren Germer, Steven Salvatore, Shawn Levy, Shixiu Wu, Nicholas Tatonetti, Sagi Shapira, Mirella Salvatore, Massimo Loda, Lars F Westblade, Melissa Cushing, Hanna Rennert, Alison J Kriegel, Olivier Elemento, Marcin Imielinski, Alain C Borczuk*, Cem Meydan*, Robert E Schwartz*, Christopher E Mason*. Systemic Tissue and Cellular Disruption from SARS-CoV-2 Infection revealed in COVID-19 Autopsies and Spatial Omics Tissue Maps. *Co-corresponding author. Cell Reports Medicine. 2022. PMID: 35233546.

2021

Duan X, Wang H, Ho DD, Schwartz RE*, Evans T*, Chen S*. Comments on 'An airway organoid-based screen identifies a role for the HIF1α‒glycolysis axis in SARS-CoV-2 infection' J Mol Cell Biol 2021 Nov 30; doi: 10.1093/jmcb/mjab075. PMID: 34850919. *Co-corresponding author. PMID: 34850919.

Reiterer M, Rajan M, Gómez-Banoy N, Lau JD, Gomez-Escobar LG, Gilani A, Alvarez-Mulett S, Sholle ET, Chandar V, Bram Y, Hoffman K, Rubio-Navarro A, Uhl S, Shukla AP, Goyal P, tenOever BR, Alonso LC, Schwartz RE, Schenck EJ, Safford MM, Lo JC. Hyperglycemia in Acute COVID-19 is Characterized by Adipose Tissue Dysfunction and Insulin Resistance. Cell Metab. 2021 Dec 7;33(12):2484. PMID: 34879241.

Duan X, Tang X, Nair MS, Zhang T, Qiu Y, Zhang W, Wang P, Huang Y, Xiang J, Wang H, Schwartz RE*, Ho DD*, Evans T*, Chen S*. An airway organoid-based screen identifies a role for the HIF1α-glycolysis axis in SARS-CoV-2 infection. Cell Rep. 2021 Nov 9;37(6):109920. doi: 10.1016/j.celrep.2021.109920. Epub 2021 Oct 15. PMID: 34731648. *Co-corresponding author.

Shilpa Tiwari-Heckler, Eric U. Yee, Yusuf Yalcin, Jiwoon Park, Duc Nguyen, Eva Csizmadia, Nezam Afdhal1, Wenda Gao, Kenneth J. Mukamal, Simon C. Robson, Michelle Lai, Robert E. Schwartz*, Z. Gordon Jiang*. Adenosine deaminase 2 produced by infiltrative monocytes promotes liver fibrosis in nonalcoholic fatty liver disease. Cell Rep. 2021 Oct 26;37(4):109897. PMID: 34706243. *Co-corresponding author.

Nilsson-Payant BE, Uhl S, Grimont A, Doane AS, Cohen P, Patel RS, Higgins CA, Acklin JA, Bram Y, Chandar V, Blanco-Melo D, Panis M, Lim JK, Elemento O, Schwartz RE, Rosenberg BR, Chandwani R, tenOever BR. The NF-κB Transcriptional Footprint Is Essential for SARS-CoV-2 Replication. J Virol. 2021 Nov 9;95(23):e0125721. PMID: 34523966.

Rodrigo R Rafagnin Duarte, Dennis Copertino, Luis Iñiguez, Jez Marston, Yaron Bram, Yuling Han, Robert Schwartz, Shuibing Chen, Douglas Nixon, Timothy Powell. Identifying FDA-approved drugs with multimodal properties against COVID-19 using a data-driven approach and a lung organoid model of SARS-CoV-2 entry. Mol Med. 2021 Sep 9;27(1):105. PMID: 34503440.

Liuliu Yang, Benjamin E Nilsson-Payant, Yuling Han, Fabrice Jaffré, Jiajun Zhu, Pengfei Wang, Tuo Zhang, David Redmond, Sean Houghton, Rasmus Møller, Lucia Carrau, Shu Horiuchi, Marisa Goff, Jean K Lim, Yaron Bram, Chanel Richardson, Vasuretha Chandar, Alain Borczuk, Yaoxing Huang, Jenny Xiang, David D Ho*, Robert E Schwartz*, Todd Evans*, Shuibing Chen*. Cardiomyocytes Recruit Monocytes upon SARS-CoV-2 Infection by Secreting CCL2. Stem Cell Reports. 2021 Sep 14;16(9):2274-2288. PMID: 34403650. *Co-corresponding author.

Tang X, Uhl S, Zhang T, Xue D, Li B, Vandana JJ, Acklin JA, Bonnycastle LL, Narisu N, Erdos MR, Bram Y, Chandar V, Chong ACN, Lacko LA, Min Z, Lim JK, Borczuk AC, Xiang J, Naji A, Collins FS, Evans T, Liu C, tenOever BR*, Schwartz RE*, Chen S*. SARS-CoV-2 infection induces beta cell transdifferentiation. Cell Metab. 2021 May 19:S1550-4131(21)00232-1. doi: 10.1016/j.cmet.2021.05.015. Online ahead of print. PMID: 34081913 *Co-corresponding author.

André Figueiredo Rendeiro, Hiranmayi Ravichandran, Yaron Bram, Steven Salvatore, Alain Borczuk*, Olivier Elemento*, and RE Schwartz* The spatial landscape of lung pathology during COVID-19 progression. Nature. Nature. 2021 May;593(7860):564-569. doi: 10.1038/s41586-021-03475-6. Epub 2021 Mar 29. PMID: 33780969

Melms JC, Biermann J, Huang H, Wang Y, Nair A, Tagore S, Katsyv I, Rendeiro AF, Amin AD, Schapiro D, Frangieh CJ, Luoma AM, Filliol A, Fang Y, Ravichandran H, Clausi MG, Alba GA, Rogava M, Chen SW, Ho P, Montoro DT, Kornberg AE, Han AS, Bakhoum MF, Anandasabapathy N, Suárez-Fariñas M, Bakhoum SF, Bram Y, Borczuk A, Guo XV, Lefkowitch JH, Marboe C, Lagana SM, Del Portillo A, Zorn E, Markowitz GS, Schwabe RF, Schwartz RE*, Elemento O*, Saqi A*, Hibshoosh H*, Que J*, Izar B*. A molecular single-cell lung atlas of lethal COVID-19. Nature. 2021 Jul;595(7865):114-119. doi: 10.1038/s41586-021-03569-1. Epub 2021 Apr 29. PMID: 33915568. *Co-corresponding author.

Macpherson D, Park J, Bram Y, and RE Schwartz. Peptide-based scaffolds for the Culture and maintenance of primary human hepatocytes. Scientific Reports (11): 6772 (2021). PMID: 33762604.

Liuliu Yang, Yuling Han, Fabrice Jaffré, Benjamin E. Nilsson-Payant, Yaron Bram, Pengfei Wang, Jiajun Zhu, Tuo Zhang, David Redmond, Sean Houghton, Tristan Jordan, Yaoxing Huang, Jenny Xiang, David D. Ho,*, Benjamin R. tenOever,*, Robert E. Schwartz*, Todd Evans*, Shuibing Chen,* An Immuno-Cardiac Model for Macrophage-Mediated Inflammation in COVID-19 Hearts. Circulation Research. 2021. PMID: 33853355. *Co-corresponding author.

AE Livanos, D Jha, F Cossarini, AS. Gonzalez-Reiche, M Tokuyama, T Aydillo, TL Parigi, MS. Ladinsky, I Ramos, K Dunleavy, B Lee, R Dixon, ST Chen, G Martinez-Delgado, S Nagula, EA Bruce, HM Ko, BS Glicksberg, G Nadkarni, E Pujadas, J Reidy, S Naymagon, A Grinspan, Jawad Ahmad, Michael Tankelevich, Y Bram, R Gordon, K Sharma,1,2 J Houldsworth, GJ. Britton, A Chen-Liaw, Matthew P. Spindler, Tamar Plitt, P Wang, Andrea Cerutti, Jeremiah J. Faith, Jean-Frederic Colombel, E Kenigsberg, C Argmann, M Merad, S Gnjatic, N Harpaz, S Danese, C Cordon-Cardo, Adeeb Rahman, RE Schwartz NA Kumta, A Aghemo, PJ. Bjorkman, F Petralia, HV Bakel, A Garcia-Sastre, and Saurabh Mehandru. Intestinal host response to SARS-CoV-2 infection and COVID-19 outcomes in patients with gastrointestinal symptoms. Gastroenterology. 2021 Mar 4 doi: 10.1053/j.gastro.2021.02.056 PMID: 33676971

Daniel J. Butler, Christopher Mozsary, Cem Meydan, David Danko, Jonathan Foox, Joel Rosiene, Alon Shaiber, Ebrahim Afshinnekoo, Matthew MacKay, Fritz J. Sedlazeck, Nikolay A. Ivanov, Maria Sierra, Diana Pohle, Michael Zietz, Undina Gisladottir, VijendraRamlall, Craig D.Westover, Krista Ryon, Benjamin Young, Chandrima Bhattacharya, Phyllis Ruggiero, Bradley W. Langhorst, Nathan Tanner, Justyna Gawrys,DmitryMeleshko, Dong Xu, Peter A. D. Steel, Amos J. Shemesh, Jenny Xiang, Jean Thierry-Mieg, Danielle Thierry-Mieg, Angelika Iftner, Daniela Bezdan, John Sipley, Lin Cong, Arryn Craney, Priya Velu, Ari M. Melnick, Iman Hajirasouliha, Stacy M. Horner, Thomas Iftner, Mirella Salvatore, Massimo Loda, Lars F. Westblade, Melissa Cushing, Shawn Levy, Shixiu Wu, Nicholas Tatonetti, Robert E. Schwartz*, Marcin Imielinski*, Hanna Rennert*, Christopher E. Mason* Shotgun Transcriptome and Isothermal Profiling of SARS-CoV-2 Infection Reveals Unique Host Responses, Viral Diversification, and Drug Interactions. Nature Communications Currently In press. *Co-corresponding author.

D Bhattacharya, B Basta, JM Mato, A Craig, D Fernández-Ramos, F Lopitz-Otsoa, D Tsvirkun, L Hayardeny, V Chandar, RE Schwartz, A Villanueva, SL Friedman. Aramchol Downregulates Stearoyl CoA-Desaturase 1 in Hepatic Stellate Cells to Attenuate Cellular Fibrogenesis. JHEP Reports. In Press.

Michael J Corley, Alina PS Pang, Kush Dody, Philip A Mudd, Bruce K Patterson, Harish Seethamraju, Yaron Bram, Michael J Peluso, Leonel Torres, Nikita S Iyer, Thomas A Premeaux, Stephen T Yeung, Vasuretha Chandar, Alain Borczuk, RE Schwartz, Timothy J Henrich, Steven G Deeks, Jonah B Sacha, Lishomwa C Ndhlovu Genome‐wide DNA methylation profiling of peripheral blood reveals an epigenetic signature associated with severe COVID‐19. Journal of Leukocyte Biology. J Leukoc Biol 2021 Jan 19. doi: 10.1002/JLB.5HI0720-466R. PMID: 33464637.

C Gaebler, Z Wang, JCC Lorenzi, F Muecksch, S Finkin, M Tokuyama, MS Ladinsky, A Cho, M Jankovic, DS Babajew, TY Oliveira, M Cipolla, C Viant, CO Barnes, Y Bram, T Hagglof, P Mendoza, G Breton, A Hurley, M Turroja, K Gordon, KG Millard, V Ramos, F Schmidt, Y Weisblum, D Jha, M Tankelevich, G Martinez-Delgado, J Yee, R Patel, J Dizon, CU O'Brien, I Shimeliovich, DF Robbiani, Z Zhao, A Gazumyan, RE Schwartz, T Hatziioannou, PJ Bjorkman, S Mehandru, PD Bieniasz, M Caskey, MC Nussenzweig Evolution of Antibody Immunity to SARS-CoV-2. Nature. 2021 Jan 18. doi: 10.1038/s41586-021-03207. PMID: 33461210

2020

Yuling Han, Liuliu Yang, Xiaohua Duan, Fuyu Duan, Benjamin E. Nilsson-Payant, Tomer M. Yaron, Pengfei Wang, Xuming Tang, Tuo Zhang, Zeping Zhao, Yaron Bram, David Redmond, Sean Houghton, Duc Nguyen, Dong Xu, Xing Wang, Skyler Uhl, Yaoxing Huang, Jared L. Johnson, Jenny Xiang, Hui Wang, Fong Cheng Pan, Lewis C. Cantley*, Benjamin R. tenOever*, David D. Ho*, Todd Evans*, Huanhuan Joyce Chen*, Robert E. Schwartz*, Shuibing Chen*. Identification of SARS-CoV-2 Inhibitors using Lung and Colonic Organoids Nature. 2020 Oct 28. doi: 10.1038/s41586-020-2901-9. *Co-corresponding author. PMID: 33116299.

Jing Chen  Dong Wang  Long‐Hai Wang  Wanjun Liu  Alan Chiu  Kaavian Shariati  Qingsheng Liu  Xi Wang  Zhe Zhong  James Webb  Robert E. Schwartz  Nikolaos Bouklas  Minglin Ma. An Adhesive Hydrogel with “Load‐Sharing” Effect as Tissue Bandages for Drug and Cell Delivery. Advanced Materials. 2020 Sep 18. doi: 10.1002/adma.202001628 PMID: 32945035

Brisa Palikuqi, Duc-Huy T Nguyen, Ge Li, Ryan Schreiner, Alessandro F Pellegata, Ying Liu, David Redmond, Fuqiang Geng1, Yang Lin, Jesus M Gómez-Salinero, Masataka Yokoyama Paul Zumbo, Tuo Zhang,  Balvir Kunar, Mavee Witherspoon, Teng Han, Alfonso M Tedeschi, Federico Scottoni,  Steven Lipkin, Lukas Dow, Olivier Elemento, Jenny Z. Xiang, Koji Shido, Jason Spence, Joe Q. Zhou, Robert E Schwartz, Paolo DeCoppi, Sina Y. Rabbany, and Shahin Rafii. Adaptable and hemodynamically stable human vasculogenic endothelial cells for organogenesis and tumorigenesis Nature. 2020 Sep 9. doi: 10.1038/s41586-020-2712 PMID: 32908310.

Ayuko Hoshino; Han Sang Kim; Linda Bojmar; Kofi Ennu Gyan; Michele Cioffi; Jonathan Hernandez; Constantinos P. Zambirinis; Goncalo Rodrigues; Henrik Molina; Soren Heissel; Milica Tesic Mark; Loic Steiner; Alberto Benito Martin; Serena Lucotti; Angela Di Giannatale; Katie Offer; Miho Nakajima; Caitlin Williams; Laura Nogués; Fanny A. Pelissier Vatter; Ayako Hashimoto; Alexander E. Davies; Daniela Freitas; Candia Kenific; Yonathan Ararso; Weston Buehring; Pernille Lauritzen; Yusuke Ogitani; Kei Sugiura; Naoko Takahashi; Masa Aleckovic; Kayleen A. Bailey; Joshua S. Jolissaint; Huajuan Wang; Ashton Harris; L. Miles Schaeffer; Zoe Posner; Vinod P. Balachandran; Yasmin Khakoo; Praveen Raju; Avigdor Scherz; Irit Sagi; Ruth Scherz-Shouval; Yosef Yarden; Moshe Oren; Mary Petriccione; Kevin De Braganca; Maria Donzelli; Cheryl Fischer; Stephanie Vitolano; Geraldine Wright; Lee Ganshaw; Mariel Marrano; Amina Ahmed; Joe DeStefano; Enrico Danzer; Michael H. Roehrl; Norman J. Lacayo; Theresa Vincent; Martin R. Weiser; Mary S. Brady; Paul Meyers; Leonard H. Wexler; Srikanth Ambati; Alexander J. Chou; Emily Slotkin; Shakeel Modak; Stephen Roberts; Ellen Basu; Daniel Diolaiti; Benjamin Krantz; Fatima Cardoso; Amber L. Simpson; Michael Berger; Charles M. Rudin; Diane Simeone; Maneesh Jain; Cyrus Ghajar; Surinder K. Batra; Ben Z. Stanger; Jack Bui; Kristy A. Brown; Vinagolu K. Rajasekhar; John H. Healey; Maria de Sousa; Kim Kramer; Sujit Sheth; Jeanine Baisch; Virginia Pascual; Todd E. Heaton; Michael P. La Quaglia; David J. Pisapia; Robert E. Schwartz; Haiying Zhang; Yuan Liu; Arti Shukla; Laurence Sarte; Yves DeClerck; Mark LaBarge; Mina J. Bissell; Paul Grandgenett; Michael Hollingsworth; Jacqueline Bromberg; Bruno Costa-Silva; Hector Peinado; Yibin Kang; Benjamin A. Garcia; Eileen O'Reilly; David Kelsen; Tanya M. Trippett; David R. Jones; Irina Matei; William R. Jarnagin; David Lyden. Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers. Cell. 2020 Aug 20;182(4):1044-1061. PMID: 32795414.

Gupta V, Gupta I, Park J, Bram Y, and Schwartz RE. Hedgehog Signaling Demarcates a Niche of Fibrogenic Peribiliary Mesenchymal Cells. Gupta V, Gupta I, Park J, Bram Y, and RE Schwartz. Hedgehog Signaling Demarcates a Niche of Fibrogenic Peribiliary Mesenchymal Cells. Gastroenterology (2020) Mar 30: doi: https://doi.org/10.1053/j.gastro.2020.03.075. PMID 32289375

Daniela Marin-Hernandez, Schwartz RE , and Douglas Nixon. Epidemiological evidence for association between higher influenza vaccine uptake in the elderly and lower COVID‐19 deaths in Italy. J Med Virol. 2020 Jun 9: 10.1002/jmv.26120. PMID 32497290.

Liuliu Yang,Yuling Han, Benjamin E. Nilsson-Payant, Vikas Gupta, Pengfei Wang, Xiaohua Duan, Xuming Tang, Jiajun Zhu, Zeping Zhao, Fabrice Jaffré, Tuo Zhang, Tae Wan Kim, Oliver Harschnitz, David Redmond, Sean Houghton, Chengyang Liu, Ali Naji, Gabriele Ciceri, Sudha Guttikonda, Yaron Bram, Duc-Huy T. Nguyen, Michele Cioffi, Vasuretha Chandar, Daisy A. Hoagland, Yaoxing Huang, Jenny Xiang, Hui Wang, David Lyden, Alain Borczuk, Huanhuan Joyce Chen, Lorenz Studer, Fong Cheng Pan, David D. Ho, Benjamin R. tenOever, Todd Evans, Robert E. Schwartz, and Shuibing Chen, A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids. Cell Stem Cell 2020 Jun 19;S1934-5909(20)30282-4. doi: 10.1016/j.stem.2020.06.015. PMID 32579880.

D Blanco-Melo, BE Nilsson-Payant, WC Liu, S Uhl, D Hoagland, R Møller, TX Jordan, K Oishi, MP, David Sachs, TT Wang, Schwartz RE *, JK Lim, RA Albrecht*, BR tenOever*. Imbalanced host response to SARS-CoV-2 drives development of COVID-19. Cell 2020 May 13;S0092-8674(20)30489-X. PMID 32416070 *Co-senior and co-corresponding authors

Kaveh Hajifathalian, Srihari Mahadev, Schwartz RE , Shawn Shah, Kartik Sampath, Felice Schnoll-Sussman, Robert Brown, David Carr-Locke, David E Cohen, and Reem Z Sharaiha. SARS-CoV-2 Infection (Coronavirus Disease 2019) for the GI Consultant. World J Gastroenterol. 2020 Apr 14; 26(14): 1546–1553. PMID 32327904

Kaveh Hajifathalian, Srihari Mahadev, Schwartz RE , Shawn Shah, Kartik Sampath, Felice Schnoll-Sussman, Robert Brown, David Carr-Locke, David E Cohen, and Reem Z Sharaiha. Gastrointestinal and Hepatic Manifestations of 2019 Novel Coronavirus Disease in a Large Cohort of Infected Patients From New York: Clinical Implications. Gastroenterology 2020 May 7;S0016-5085(20)30602-8.. PMID Gastroenterology 2020 May 7;S0016-5085(20)30602-8.

Betsy J. Barnes, Alain Borczuk, Jonathan Cools-Lartigue, James M Crawford, Philippe Guerci, Caroline Huynh, Jason S. Knight, Massimo Loda, Mark Looney, Florencia McAllister, Roni Rayes6, Stephane Renaud5, Simon Rousseau, Jonathan Spicer, Schwartz RE , Christian Con Yost, Andrew Weber, Yu Zuo,  Jose M. Adrover, Juliane Daßler-Plenker, and Mikala Egeblad Targeting potential drivers of COVID-19: the neutrophil extracellular traps. J Exp Med. 2020 Jun 1;217(6):e20200652. PMID 32302401.

Heller DA, Jena PV, Pasquali M, Kostarelos K, Delogu LG, Meidl RE, Rotkin SV, Scheinberg DA, Schwartz RE, Terrones M, Wang Y, Bianco A, Boghossian AA, Cambré S, Cognet L, Corrie SR, Demokritou P, Giordani S, Hertel T, Ignatova T, Islam MF, Iverson NM, Jagota A, Janas D, Kono J, Kruss S, Landry MP, Li Y, Martel R, Maruyama S, Naumov AV, Prato M, Quinn SJ, Roxbury D, Strano MS, Tour JM, Weisman R, Wenseleers W, Yudasaka M. Banning carbon nanotubes would be scientifically unjustified and damaging to innovation. Nat Nanotechnol. 2020 Mar;15(3):164-166. PMID 32157238

TV Galassi, M Antman-Passig, Z Yaari, J Jessurun, Schwartz RE, and DA Heller. Long-term in vivo biocompatibility of single-walled carbon nanotubes. Plos One 2020: e0226791. PMID 32374764.

2019

Gaska JM, Parsons L, Balev M, Cirincione A, Wang W, Schwartz RE, Ploss A. Conservation of cell-intrinsic immune responses in diverse nonhuman primate species. Life Sci Alliance. 2019 Oct 24;2(5). pii: e201900495. doi: 10.26508/lsa.201900495. Print 2019 Oct. PMID:31649152

Song W, Chiu A, Wang LH, Schwartz RE, Li B, Bouklas N, Bowers DT, An D, Cheong SH, Flanders JA, Pardo Y, Liu Q, Wang X, Lee VK, Dai G, Ma M. Engineering transferrable microvascular meshes for subcutaneous islet transplantation. Nat Commun. 2019 Oct 10;10(1):4602. doi: 10.1038/s41467-019-12373-5. PMID:31601796

Prescott NA, Bram Y, Schwartz RE, David Y. Targeting Hepatitis B Virus Covalently Closed Circular DNA and Hepatitis B Virus X Protein: Recent Advances and New Approaches. ACS Infect Dis. 2019 Oct 11;5(10):1657-1667. doi: 10.1021/acsinfecdis.9b00249. Epub 2019 Sep 27. PMID:31525994

Tan L, Lacko LA, Zhou T, Tomoiaga D, Hurtado R, Zhang T, Sevilla A, Zhong A, Mason CE, Noggle S, Evans T, Stuhlmann H, Schwartz RE, Chen S. Pre- and peri-implantation Zika virus infection impairs fetal development by targeting trophectoderm cells. Nat Commun. 2019 Sep 13;10(1):4155. doi: 10.1038/s41467-019-12063-2. PMID:31519912

Yarchoan M, Agarwal P, Villanueva A, Rao S, Dawson LA, Llovet JM, Finn RS, Groopman JD, El-Serag HB, Monga SP, Wang XW, Karin M, Schwartz RE, Tanabe KK, Roberts LR, Gunaratne PH, Tsung A, Brown KA, Lawrence TS, Salem R, Singal AG, Kim AK, Rabiee A, Resar L, Hoshida Y, He AR, Ghoshal K, Ryan PB, Jaffee EM, Guha C, Mishra L, Coleman CN, Ahmed MM. Recent Developments and Therapeutic Strategies against Hepatocellular Carcinoma. Cancer Res. 2019 Sep 1;79(17):4326-4330. doi: 10.1158/0008-5472.CAN-19-0803. Erratum in: Cancer Res. 2019 Nov 15;79(22):5897. PMID:31481419

Winer BY, Gaska JM, Lipkowitz G, Bram Y, Parekh A, Parsons L, Leach R, Jindal R, Cho CH, Shrirao A, Novik E, Schwartz RE, Ploss A. Analysis of Host Responses to Hepatitis B and Delta Viral Infections in a Micro-scalable Hepatic Co-culture System. Hepatology. 2020 Jan;71(1):14-30. doi: 10.1002/hep.30815. Epub 2019 Aug 9. PMID:31206195

2018

Winer BY, Shirvani-Dastgerdi E, Bram Y, Sellau J, Low BE, Johnson H, Huang T, Hrebikova G, Heller B, Sharon Y, Giersch K, Gerges S, Seneca K, Pais MA, Frankel AS, Chiriboga L, Cullen J, Nahass RG, Lutgehetmann M, Toettcher JE, Wiles MV, Schwartz RE, Ploss A. Preclinical assessment of antiviral combination therapy in a genetically humanized mouse model for hepatitis delta virus infection. Sci Transl Med. 2018 Jun 27;10(447). PMID: 29950446.

Galassi TV, Jena PV, Shah J, Ao G, Molitor E, Bram Y, Frankel A, Park J, Jessurun J, Ory DS, Haimovitz-Friedman A, Roxbury D, Mittal J, Zheng M, Schwartz RE, Heller DA. An optical nanoreporter of endolysosomal lipid accumulation reveals enduring effects of diet on hepatic macrophages in vivo. Sci Transl Med. 2018 Oct 3;10(461). pii: eaar2680. doi: 10.1126/scitranslmed.aar2680. PMID:30282694

Ding Q, Nimgaonkar I, Archer NF, Bram Y, Heller B, Schwartz RE, Ploss A. Identification of the Intragenomic Promoter Controlling Hepatitis E Virus Subgenomic RNA Transcription. MBio. 2018 May 8;9(3). PMID: 29739903.

Man L, Park L, Bodine R, Ginsberg M, Zaninovic N, Schatt,am G, Schwartz RE, Rosenwaks Z, and D James. Co-Transplantation of Human Ovarian Tissue with Engineered Endothelial Cells: A Cell-Based Strategy Combining Accelerated Perfusion with Direct Paracrine Delivery. J Vis Exp. 2018 May 16;(135). doi: 10.3791/57472.PMID 29863664.

Galassi T, Jena P, Shah J, Ao G, Molitor E, Bram Y, Frankel A, Park J, Jessurun J, Ory D, Haimovitz-Friedman A, Roxbury D, Mittal J, Zheng M, Schwartz RE* and D Heller*. Non-invasive detection of endolysosomal lipid accumulation in lysosomal storage and fatty liver diseases in vivo. Sci Transl Med. 2018 Oct 3;10(461). pii: eaar2680. doi: 10.1126/scitranslmed.aar2680. *Co-senior authors

Zhang H, Freitas D, Kim HS, Fabijanic K, Li Z, Chen H, Mark MT, Molina H, Martin AB, Bojmar L, Fang J, Rampersaud S, Hoshino A, Matei I, Kenific CM, Nakajima M, Mutvei AP, Sansone P, Buehring W, Wang H, Jimenez JP, Cohen-Gould L, Paknejad N, Brendel M, Manova-Todorova K, Magalhães A, Ferreira JA, Osório H, Silva AM, Massey A, Cubillos-Ruiz JR, Galletti G, Giannakakou P, Cuervo AM, Blenis J, Schwartz RE, Brady MS, Peinado H, Bromberg J, Matsui H, Reis CA, Lyden D. Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation. Nat Cell Biol. 2018 Mar;20(3):332-343. doi: 10.1038/s41556-018-0040-4. Epub 2018 Feb 19. PMID: 29459780

Nimgaonkar I, Ding Q, Schwartz RE, and Alexander Ploss. Hepatitis E virus: advances and challenges. Nature Reviews Gastroenterology and Hepatology. 2018 Feb;15(2):96-110 PMID: 29162935

2017

Lu YC, Fu DF, An D, Chiu A, Schwartz RE, Nikitin AY, and Minglin Ma Scalable Production and Cryo-storage of Organoids Using Core-shell Decoupled Hydrogel Capsules. Adv Biosyst. 2017 Dec;1(12). pii: 1700165. doi: 10.1002/adbi.201700165. Epub 2017 Nov 22.

Koppe T, Patchen B, Cheng A, Bhasin M, Vulpe C, Schwartz RE, Moreno-Navarrete j, Fernandez-Real JM, Pissios P, and PJ Fraenkel. Nicotinamide N-methyltransferase expression decreases in iron overload exacerbating toxicity in mouse hepatocytes. Hepatology Communications. 2017 Sep 11;1(8):803-815. PMID: 29404495

Zhou T, Tan L, Cederquist GY, Fan Y, Hartley BJ, Mukherjee S, Tomishima M, Brennand KJ, Zhang Q, Schwartz RE, Evans T, Studer L, and Chen S. High-Content Screening in hPSC-Neural Progenitors Identifies Drug Candidates that Inhibit Zika Virus Infection in Fetal-like Organoids and Adult Brain Cell Stem. Cell. 2017 Aug 3;21(2):274-283. PMID 28736217

2016

Sharaiha RZ, Kumta NA, Saumoy M, Desai AP, Sarkisian AM, Benevenuto A, Tyberg A, Kumar R, Igel L, Verna EC, Schwartz R, Frissora C, Shukla A, Aronne LJ, Kahaleh M. Endoscopic Sleeve Gastroplasty Significantly Reduces Body Mass Index and Metabolic Complications in Obese Patients. Clin Gastroenterol Hepatol. 2016 Dec 22. PMID: 28017845

Y. Bram, Frankel A, and Schwartz RE Pluripotent Stem Cell-Derived Hepatocyte-like Cells: A Tool to Study Infectious Disease. Current Pathobiology Reports September 2016, Volume 4, Issue 3, pp 147–156. PMID: 29910973

Shirvani-Dastgerdi E, Schwartz RE, Ploss A. Hepatocarcinogenesis associated with hepatitis B, delta and C viruses. Curr Opin Virol. 2016 Aug 5;20:1-10. PMID: 27504999

V. Ramanan, Trehan, K., Ong, M. - L., Luna, J. M., Hoffmann, H. - H., Espiritu, C., Sheahan, T. P., Chandrasekar, H., Schwartz, R. E., Christine, K. S., Rice, C. M., van Oudenaarden, A., and Bhatia, S. N., Viral genome imaging of hepatitis C virus to probe heterogeneous viral infection and responses to antiviral therapies. Virology, vol. 494, pp. 236 - 247, 2016. PMID: 27128351

2015

Song W, Lu YC, Frankel A, An D, Schwartz RE* and Minglin M*. Engraftment of human induced pluripotent stem cell derived hepatocytes in immunocompetent mice mice via 3D co-aggregation and encapsulation. *Co-corresponding authors. Sci Reports 2015 Nov 23; 5:16884-89.

El-Shamy A, Eng FJ, Doyle EH, Klepper AL, Sun X, Sangiovanni A, Iavarone M, Colombo M, Schwartz RE, Hoshida Y, Branch AD. A Cell Culture System for Distinguishing Hepatitis C Viruses with and without Liver Cancer-related Mutations in the Viral Core Gene. J Hepatol. 2015 Jul 25. pii: S0168-8278(15)00515-2. PMID: 26220749

Costa-Silva B, Aiello NM, Ocean AJ, Singh S, Zhang H, Thakur BK, Becker A, Hoshino A, Mark MT, Molina H, Xiang J, Zhang T, Theilen TM1, García-Santos G, Williams C, Ararso Y, Huang Y, Rodrigues G, Shen TL, Labori KJ, Lothe IM, Kure EH, Hernandez J, Doussot A, Ebbesen SH, Grandgenett PM, Hollingsworth MA, Jain M, Mallya K, Batra SK, Jarnagin WR, Schwartz RE, Matei , Peinado H, Stanger BZ, Bromberg J, Lyden D. Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver. Nat Cell Biol. 2015 May 18. PMID: 25985394

Ramanan V, Shlomai A, Cox D, Schwartz RE, Michailidis E, Bhatta A, Scott D, Zhang F, Rice CM, and Sangeeta N. Bhatia CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus. Scientific Reports. 2015 Jun 2;5:10833 PMID: 26035283

Avior Y, Levy G, Zimerman M, Kitsberg D, Schwartz R, Sadeh R, Moussaieff A, Cohen M, Itskovitz-Eldor J, Nahmias Y. Microbial-derived lithocholic acid and vitamin K2 drive the metabolic maturation of pluripotent stem cells-derived and fetal hepatocytes. Hepatology. 2015 March 22. (Published Online). PMID: 25808545

Ng S, Schwartz RE, March S, Galstian A, Gural N, Shan J, Prabhu M, Mota MM, and Bhatia SN. Human iPSC-derived Hepatocyte-like cells support Plasmodium Liver-Stage Infection in Vitro. Stem Cell Reports. 2015 Feb 4. (15) S2213-6711. PMID: 25660406

Y-C. Lu, W. Song, D. An, B. J. Kim, R. Schwartz, M. Wu and M. Ma Designing Compartmentalized Hydrogel Microparticles for Cell Encapsulation and Scalable 3D Cell Culture. J. Mater. Chem. B 2015, 3, 353.

2014 and Earlier

Chaturvedi, RR, Stevens, KR, Solorzano, RD, Schwartz, RE, Eyckmans, J, Baranski, JD, Stapleton, S, Bhatia, SN, and Chen, CS.  Patterning vascular networks in vivo for tissue engineering applications. Tissue Engineering Part C. (2014, Nov 12). PMID: 25390971

Shlomai, A*, Schwartz, RE*, Ramanan, V*, Bhatta, A, de Jonga, YP, Bhatia, SN, and Rice, CM (2014): Modeling host interactions with hepatitis B virus using primary and induced pluripotent stem cell-derived hepatocellular systems. PNAS. 111(33): 12193-12198. *1st Coauthors PMID: 25092305

Li, CY, Stevens, KR, Schwartz, RE, Alejandro, BS, Huang, JH, and Bhatia, SN. Micropatterned cell-cell interactions enable functional encapsulation of primary hepatocytes in hydrogel microtissues. Tissue Eng Part A. 2014 doi:10.1089/ten.TEA.2013.0667 PMID: 24498910

R.E. Schwartz, RE, Fleming, HE, Khetani, SR, and Bhatia, SN (2014): Pluripotent stem cell-derived hepatocyte-like cells. Biotechnology Advances. 32: 504-513. PMID: 24440487

Shan J, Schwartz RE, Ross NT, Logan DJ, Duncan SA, North TE, Goessling W, Carpenter AE, and Bhatia SN High-throughput identification of small molecules for human hepatocyte expansion and iPS differentiation. Nature Chemical Biology. 2013 9: 514-520 PMID: 23728495

Stevens, KR, Ungrin, MD, Schwartz, RE, Ng, SY, Carvalho, B, Christine, KS, Chaturvedi, R, Li, CY, Zandstra, PW, Chen, CS, and Bhatia, SN (2013): InVERT molding for scalable control of tissue microarchitecture. Nature Communications. 4:1847

Schwartz RE, Trehan KT,Andrus L, Sheahan TP, Ploss A, Duncan SA, Rice, CM, andBhatia SN. Modeling hepatitis Cvirus infection using human induced pluripotent stem cells. Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2544-8. 

Chen, AA, Thomas, DK, Ong, LL, Schwartz, RE, Golub, TR, Bhatia, SN (2011):Humanized mice with ectopic artificial liver tissues. Proc Natl Acad Sci U S A. 2011 106: 11842-11847.

Souza RF, Schwartz RE, Mashimo H.. Esophageal Stem Cells and 3D-cell culture models. 2011 Sep;1232:316-22.

Schwartz, RE and Verfaillie CM Hepatic Stem Cells. Methods Mol Biol. 2010;640:167-79. 

Gupta K, Schwartz RE, Gupta P, Hebbel RP (2009): Thrombospondin Inhibitis VEGF-Induced Endothelial Survival and Cell Cycle Progression. The Open Circulation and Vascular Journal 2009;2(1) 3826-3829.

Sahin MB, Schwartz, RE, Buckley SM, Hereman Y, Chase L, Hu WS, Verfaillie CM. Isolation and characterization of a novel population of progenitor cells from unmanipulated rat liver. Liver Transplantation. 2008 Mar; 14(3):333-45. 

Schwartz RE, Nahmias, Y, Verfaillie CM, Odde DJ. Endothelium-mediated hepatocyte recruitment in the establishment of liver-like tissue in vitro. Tissue Eng. 2006 Jun;12(6):1627-38.

Schwartz RE, Linehan JL, Painschab MS, Hu WS, Verfaillie CM, Kaufman DS. Defined Conditions for Development of Functional Hepatic Cells from Human Embryonic Stem Cells. Stem Cells Dev. 2005 Dec;14(6):643-55.

Nahmias, Y, Schwartz RE, Verfaillie CM, Odde DJ. Laser-guided direct writing for three-dimensional tissue engineering. Biotechnol Bioeng. 2005 Oct 20; 92(2) 129-136.

Gupta K, Kshirsagar S, Chang L, Schwartz R, Law PY, Yee D, Hebbel RP. Morphine stimulates angiogenesis by activating proangiogenic and survival-promoting signaling and promotes breast tumor growth. Cancer Res. 2002 Aug 1; 62(15):4491-8.

 Jiang, Y, B. Jahagirdar, RL Reinhardt, RE Schwartz, CD Keene, X Otiz, M Reyes, T Lenvik, T Lund, M Blackstad, J Du, S Aldrich, A Lisberg, W Low, DA Largaespada, and CM Verfaillie., Pluripotent Nature of Adult Marrow Derived Mesenchymal Stem Cells. Nature. 2002 July 4; 418: 41-49.

Schwartz RE, Reyes M, Koodie L, Jiang Y, Blackstad M, Lund T, Lenvik T, Johnson S, Hu WS, Verfaillie CM. Multipotent Adult Progenitor Cells from Bone Marrow differentiate into functional hepatocyte-like cells. Journal of Clinical Investigation. 2002 May 15; 109: 1291-1302.

REVIEWS & EDITORIALS

S Sinha, N Hassan, Robert E. Schwartz. Organelle stress and alterations in inter-organelle crosstalk during liver fibrosis. Hepatology Journal. 2023 Jan 3.

Savannah L Herbek, Marie C Smithgall, Elisabeth A Murphy, RE Schwartz, Shuibing Chen, Laura E Riley, Heidi Stuhlmann, Yawei J Yang, Ria Goswami. Human Maternal-Fetal Interface Cellular Models to Assess Antiviral Drug Toxicity during Pregnancy. Reproductive Medicine. 3(4): 303-319.

SS Huppert and RE Schwartz. Multiple Facets of Cellular Homeostasis and Regeneration of the Mammalian Liver. Annual Review of Physiology 85.

S Sinha, RE Schwartz. Human biliary epithelial cells for regenerative medicine. Cell Stem Cell 29 (3), 345-347.

DF Nixon*, RE. Schwartz*, and LC Ndhlovu*. Booster vaccines for COVID-19 vaccine breakthrough cases? Lancet. 2022 Mar 26;399(10331):1224. *Co-corresponding author. PMID: 35339219.

Bram Y, Nguyen DT, Gupta V, Park J, Richardson C, Schwartz RE. Cell and Tissue Therapy for the Treatment of Chronic Liver Disease. Annu Rev Biomed Eng. 2021 May 11. doi: 10.1146/annurev-bioeng-112619-044026. PMID: 33974812.

Yarchoan M, Agarwal P, Villanueva A, Rao S, Dawson L, Llovet JM, Finn RS, Groopman JD, El-Serag HB, Monga SP, Wang XW, Karin M, Schwartz RE, Tanabe KK, Roberts LR, Gunaratne PH, Tsung A, Brown KA, Lawrence TS, Salem R, Singal AG, Kim AK, Rabiee A, Resar L, Hoshida Y, He AR, Ghoshal K, Ryan PB, Jaffee EM, Guha C, Mishra L, Coleman CN, Ahmed MM. Recent Developments and Therapeutic Strategies against Hepatocellular Carcinoma. Cancer Res. 2019 Sep 1; 79(17):4326-4330. PMID: 31481419

Prescott NA, Bram Y, Schwartz RE, David Y. Targeting Hepatitis B Virus cccDNA and HBx: Recent Advances and New Approaches. ACS Infect Dis. 2019 Sep 17. PMID: 31525994

Nimgaonkar I, Ding Q, Schwartz RE, and Alexander Ploss. Hepatitis E virus: advances and challenges. Nature Reviews Gastroenterology and Hepatology. 2018 Feb;15(2):96-110 PMID: 29162935

Y. Bram, Frankel A, and Schwartz RE Pluripotent Stem Cell-Derived Hepatocyte-like Cells: A Tool to Study Infectious Disease Current Pathobiology Reports September 2016, Volume 4, Issue 3, pp 147–156. PMID: 29910973

Shirvani-Dastgerdi E, Schwartz RE, Ploss A. Hepatocarcinogenesis associated with hepatitis B, delta and C viruses. Curr Opin Virol. 2016 Aug 5; 20:1-10. PMID: 27504999

Schwartz, RE, Fleming, HE, Khetani, SR, and Bhatia, SN (2014): Pluripotent stem cell-derived hepatocyte-like cells. Biotechnology Advances. 32: 504-513. PMID: 24440487

Souza RF, Schwartz RE, Mashimo H. Esophageal Stem Cells and 3D-cell culture models. 2011 Sep; 1232:316-22.

BOOKS & BOOK CHAPTERS

Schwartz RE. and Giridharan Ramsingh. “Myelodysplasia, Bone Marrow Failure Syndromes, and Other Causes of Pancytopenia.” New York, NY: Lipincott, 2008. 78-89.

Schwartz RE. and Catherine Verfaillie. “Adult Stem Cell Plasticity.” Human Embryonic Stem Cells. New York, NY: Bios Scientific Publishers, 2005. 45-60.

Verfaillie CM, Schwartz R, Reyes M, Jiang Y. Unexpected potential of adult stem cells. Ann N Y Acad Sci. 2003 May; 996:231-4.