PUBLICATIONS


ORIGINAL PEER REVIEWED ARTICLES

Winer BY, Shirvani-Dastgerdi E, Bram Y, Sellau J, Low BE, Johnson H, Huang T, Hrebikova G, Heller B, Sharon Y, Giersch K, Gerges S, Seneca K, Pais MA, Frankel AS, Chiriboga L, Cullen J, Nahass RG, Lutgehetmann M, Toettcher JE, Wiles MV, Schwartz RE, Ploss A. Preclinical assessment of antiviral combination therapy in a genetically humanized mouse model for hepatitis delta virus infection. Sci Transl Med. 2018 Jun 27;10(447). PMID: 29950446.

Ding Q, Nimgaonkar I, Archer NF, Bram Y, Heller B, Schwartz RE, Ploss A. Identification of the Intragenomic Promoter Controlling Hepatitis E Virus Subgenomic RNA Transcription. MBio. 2018 May 8;9(3). PMID: 29739903.

Man L, Park L, Bodine R, Ginsberg M, Zaninovic N, Schatt,am G, Schwartz RE, Rosenwaks Z, and D James. Co-Transplantation of Human Ovarian Tissue with Engineered Endothelial Cells: A Cell-Based Strategy Combining Accelerated Perfusion with Direct Paracrine Delivery PMID 29863664.

Lu YC, Fu DF, An D, Chiu A, Schwartz RE, Nikitin AY, and Minglin Ma Scalable Production and Cryo-storage of Organoids Using Core-shell Decoupled Hydrogel Capsules. Advanced Biosystems. In press.

Galassi T, Jena P, Shah J, Ao G, Molitor E, Bram Y, Frankel A, Park J, Jessurun J, Ory D, Haimovitz-Friedman A, Roxbury D, Mittal J, Zheng M, Schwartz RE* and D Heller*. Non-invasive detection of endolysosomal lipid accumulation in lysosomal storage and fatty liver diseases in vivo. In Press. *Co-senior authors

Zhang H, Freitas D, Kim HS, Fabijanic K, Li Z, Chen H, Mark MT, Molina H, Martin AB, Bojmar L, Fang J, Rampersaud S, Hoshino A, Matei I, Kenific CM, Nakajima M, Mutvei AP, Sansone P, Buehring W, Wang H, Jimenez JP, Cohen-Gould L, Paknejad N, Brendel M, Manova-Todorova K, Magalhães A, Ferreira JA, Osório H, Silva AM, Massey A, Cubillos-Ruiz JR, Galletti G, Giannakakou P, Cuervo AM, Blenis J, Schwartz R, Brady MS, Peinado H, Bromberg J, Matsui H, Reis CA, Lyden D. Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation. Nat Cell Biol. 2018 Mar;20(3):332-343. doi: 10.1038/s41556-018-0040-4. Epub 2018 Feb 19. PMID: 29459780

Nimgaonkar I, Ding Q, Schwartz RE, and Alexander Ploss. Hepatitis E virus: advances and challenges. Nature Reviews Gastroenterology and Hepatology. 2018 Feb;15(2):96-110 PMID: 29162935

Koppe T, Patchen B, Cheng A, Bhasin M, Vulpe C, Schwartz RE, Moreno-Navarrete j, Fernandez-Real JM, Pissios P, and PJ Fraenkel. Nicotinamide N-methyltransferase expression decreases in iron overload exacerbating toxicity in mouse hepatocytes. Hepatology Communications. 2017 Sep 11;1(8):803-815. PMID: 29404495

Zhou T, Tan L, Cederquist GY, Fan Y, Hartley BJ, Mukherjee S, Tomishima M, Brennand KJ, Zhang Q, Schwartz RE, Evans T, Studer L, and Chen S High-Content Screening in hPSC-Neural Progenitors Identifies Drug Candidates that Inhibit Zika Virus Infection in Fetal-like Organoids and Adult Brain Cell Stem Cell. 2017 Aug 3;21(2):274-283. PMID 28736217

Sharaiha RZ, Kumta NA, Saumoy M, Desai AP, Sarkisian AM, Benevenuto A, Tyberg A, Kumar R, Igel L, Verna EC, Schwartz R, Frissora C, Shukla A, Aronne LJ, Kahaleh M. Endoscopic Sleeve Gastroplasty Significantly Reduces Body Mass Index and Metabolic Complications in Obese Patients. Clin Gastroenterol Hepatol. 2016 Dec 22. PMID: 28017845

Y. Bram, Frankel A, and Schwartz RE Pluripotent Stem Cell-Derived Hepatocyte-like Cells: A Tool to Study Infectious Disease Current Pathobiology Reports September 2016, Volume 4, Issue 3, pp 147–156. PMID: 29910973

Shirvani-Dastgerdi E, Schwartz RE, Ploss A. Hepatocarcinogenesis associated with hepatitis B, delta and C viruses. Curr Opin Virol. 2016 Aug 5;20:1-10. PMID: 27504999

V. Ramanan, Trehan, K., Ong, M. - L., Luna, J. M., Hoffmann, H. - H., Espiritu, C., Sheahan, T. P., Chandrasekar, H., Schwartz, R. E., Christine, K. S., Rice, C. M., van Oudenaarden, A., and Bhatia, S. N., “Viral genome imaging of hepatitis C virus to probe heterogeneous viral infection and responses to antiviral therapies”, Virology, vol. 494, pp. 236 - 247, 2016. PMID: 27128351

Song W, Lu YC, Frankel A, An D, Schwartz RE* and Minglin M*. Engraftment of human induced pluripotent stem cell derived hepatocytes in immunocompetent mice mice via 3D co-aggregation and encapsulation. *Co-corresponding authors. Sci Reports 2015 Nov 23; 5:16884-89.

El-Shamy A, Eng FJ, Doyle EH, Klepper AL, Sun X, Sangiovanni A, Iavarone M, Colombo M, Schwartz RE, Hoshida Y, Branch AD. A Cell Culture System for Distinguishing Hepatitis C Viruses with and without Liver Cancer-related Mutations in the Viral Core Gene. J Hepatol. 2015 Jul 25. pii: S0168-8278(15)00515-2. PMID: 26220749

Costa-Silva B, Aiello NM, Ocean AJ, Singh S, Zhang H, Thakur BK, Becker A, Hoshino A, Mark MT, Molina H, Xiang J, Zhang T, Theilen TM1, García-Santos G, Williams C, Ararso Y, Huang Y, Rodrigues G, Shen TL, Labori KJ, Lothe IM, Kure EH, Hernandez J, Doussot A, Ebbesen SH, Grandgenett PM, Hollingsworth MA, Jain M, Mallya K, Batra SK, Jarnagin WR, Schwartz RE, Matei , Peinado H, Stanger BZ, Bromberg J, Lyden D. Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver. Nat Cell Biol. 2015 May 18. PMID: 25985394

Ramanan V, Shlomai A, Cox D, Schwartz RE, Michailidis E, Bhatta A, Scott D, Zhang F, Rice CM, and Sangeeta N. Bhatia CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus. Scientific Reports. 2015 Jun 2;5:10833 PMID: 26035283

Avior Y, Levy G, Zimerman M, Kitsberg D, Schwartz R, Sadeh R, Moussaieff A, Cohen M, Itskovitz-Eldor J, Nahmias Y. Microbial-derived lithocholic acid and vitamin K2 drive the metabolic maturation of pluripotent stem cells-derived and fetal hepatocytes. Hepatology. 2015 March 22. (Published Online). PMID: 25808545

Ng S, Schwartz RE, March S, Galstian A, Gural N, Shan J, Prabhu M, Mota MM, and Bhatia SN. Human iPSC-derived Hepatocyte-like cells support Plasmodium Liver-Stage Infection in Vitro. Stem Cell Reports. 2015 Feb 4. (15) S2213-6711. PMID: 25660406

Y-C. Lu, W. Song, D. An, B. J. Kim, R. Schwartz, M. Wu and M. Ma Designing Compartmentalized Hydrogel Microparticles for Cell Encapsulation and Scalable 3D Cell Culture. J. Mater. Chem. B 2015, 3, 353.

Chaturvedi, RR, Stevens, KR, Solorzano, RD, Schwartz, RE, Eyckmans, J, Baranski, JD, Stapleton, S, Bhatia, SN, and Chen, CS.  Patterning vascular networks in vivo for tissue engineering applications. Tissue Engineering Part C. (2014, Nov 12). PMID: 25390971

Shlomai, A*, Schwartz, RE*, Ramanan, V*, Bhatta, A, de Jonga, YP, Bhatia, SN, and Rice, CM (2014): Modeling host interactions with hepatitis B virus using primary and induced pluripotent stem cell-derived hepatocellular systems. PNAS. 111(33): 12193-12198. *1st Coauthors PMID: 25092305

Li, CY, Stevens, KR, Schwartz, RE, Alejandro, BS, Huang, JH, and Bhatia, SN. Micropatterned cell-cell interactions enable functional encapsulation of primary hepatocytes in hydrogel microtissues. Tissue Eng Part A. doi:10.1089/ten.TEA.2013.0667 PMID: 24498910

R.E. Schwartz, RE, Fleming, HE, Khetani, SR, and Bhatia, SN (2014): Pluripotent stem cell-derived hepatocyte-like cells. Biotechnology Advances. 32: 504-513. PMID: 24440487

Shan J, Schwartz RE, Ross NT, Logan DJ, Duncan SA, North TE, Goessling W, Carpenter AE, and Bhatia SN High-throughput identification of small molecules for human hepatocyte expansion and iPS differentiation. Nature Chemical Biology. 2013 9: 514-520 PMID: 23728495

Stevens, KR, Ungrin, MD, Schwartz, RE, Ng, SY, Carvalho, B, Christine, KS, Chaturvedi, R, Li, CY, Zandstra, PW, Chen, CS, and Bhatia, SN (2013): InVERT molding for scalable control of tissue microarchitecture, Nature Communications. 4:1847

Schwartz RE, Trehan KT,Andrus L, Sheahan TP, Ploss A, Duncan SA, Rice, CM, andBhatia SN. Modeling hepatitis Cvirus infection using human induced pluripotent stem cells. Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2544-8. 

Chen, AA, Thomas, DK, Ong, LL, Schwartz, RE, Golub, TR, Bhatia, SN (2011):Humanized mice with ectopic artificial liver tissues. Proc Natl Acad Sci U S A. 2011 106: 11842-11847.

Souza RF, Schwartz RE, Mashimo H.. Esophageal Stem Cells and 3D-cell culture models. 2011 Sep;1232:316-22.

Schwartz, RE and Verfaillie CM Hepatic Stem Cells. Methods Mol Biol. 2010;640:167-79. 

Gupta K, Schwartz RE, Gupta P, Hebbel RP (2009): Thrombospondin Inhibitis VEGF-Induced Endothelial Survival and Cell Cycle Progression. The Open Circulation and Vascular Journal 2009;2(1) 3826-3829.

Sahin MB, Schwartz, RE, Buckley SM, Hereman Y, Chase L, Hu WS, Verfaillie CM. Isolation and characterization of a novel population of progenitor cells from unmanipulated rat liver. Liver Transplantation. 2008 Mar; 14(3):333-45. 

Schwartz RE, Nahmias, Y, Verfaillie CM, Odde DJ. Endothelium-mediated hepatocyte recruitment in the establishment of liver-like tissue in vitro. Tissue Eng. 2006 Jun;12(6):1627-38.

Schwartz RE, Linehan JL, Painschab MS, Hu WS, Verfaillie CM, Kaufman DS. Defined Conditions for Development of Functional Hepatic Cells from Human Embryonic Stem Cells. Stem Cells Dev. 2005 Dec;14(6):643-55.

Nahmias, Y, Schwartz RE, Verfaillie CM, Odde DJ. Laser-guided direct writing for three-dimensional tissue engineering. Biotechnol Bioeng. 2005 Oct 20; 92(2) 129-136.

Gupta K, Kshirsagar S, Chang L, Schwartz R, Law PY, Yee D, Hebbel RP. Morphine stimulates angiogenesis by activating proangiogenic and survival-promoting signaling and promotes breast tumor growth. Cancer Res. 2002 Aug 1; 62(15):4491-8.

 Jiang, Y, B. Jahagirdar, RL Reinhardt RE Schwartz, CD Keene, X Otiz, M Reyes, T Lenvik, T Lund, M Blackstad, J Du, S Aldrich, A Lisberg, W Low, DA Largaespada, and CM Verfaillie., Pluripotent Nature of Adult Marrow Derived Mesenchymal Stem Cells. Nature. 2002 July 4; 418: 41-49.

Schwartz RE, Reyes M, Koodie L, Jiang Y, Blackstad M, Lund T, Lenvik T, Johnson S, Hu WS, Verfaillie CM. Multipotent Adult Progenitor Cells from Bone Marrow differentiate into functional hepatocyte-like cells. Journal of Clinical Investigation. 2002 May 15; 109: 1291-1302.


BOOKS AND BOOK CHAPTERS

Schwartz RE. and Giridharan Ramsingh. “Myelodysplasia, Bone Marrow Failure Syndromes, and Other Causes of Pancytopenia.” New York, NY: Lipincott, 2008. 78-89.

Schwartz RE. and Catherine Verfaillie. “Adult Stem Cell Plasticity.” Human Embryonic Stem Cells. New York, NY: Bios Scientific Publishers, 2005. 45-60.

Verfaillie CM, Schwartz R, Reyes M, Jiang Y. Unexpected potential of adult stem cells. Ann N Y Acad Sci. 2003 May; 996:231-4.